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KMID : 0604220070140020037
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Korean Journal Investigative Dermatology
2007 Volume.14 No. 2 p.37 ~ p.44
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Zebrafish as an in Vivo Model for the Study of Skin Cells
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Choi Tae-Young
Lee Jeung-Hoon
Kim Seong-Min
Kim Chang-Duk
Yoon Tae-Jin
Sohn Kyung-Cheol
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Abstract
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The zebrafish(Danio rerio) is a small tropical bony fish(teleost) that has emerged as an excellent vertebrate model organism because of its small size, large clutches, and physiological similarity to mammals. There are important similarities between the epidermis of zebrafish and human. In addition, zebrafish has melanin pigments on the surface, allowing simple observation of the pigmentation process without complicated experimental procedures. The zebrafish is a very useful genetic system, and many mutants with epidermal or pigmentary defects have been obtained by genetic manipulations. In this paper we review current knowledges regarding the structure, function, and development of the zebrafish skin including epidermis, dermis, and scales. We also describe a list of useful genes and their genetic application for human keratinocyte and melanocyte study.
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KEYWORD
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Epidermis, Keratinocyte, Melanocyte, Scales, Zebrafish
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